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Understanding Pathogenesis and Novel Nutritional Interventions: Addressing Mortality in the Global Necrotising Enterocolitis Market

The Necrotising Enterocolitis Market (NEC) addresses a devastating gastrointestinal disease that primarily affects premature infants, causing inflammation and necrosis of the bowel wall, often leading to perforation, sepsis, and high mortality. The market is driven by the increasing survival rates of extremely preterm infants due to advancements in neonatal intensive care, which unfortunately exposes a larger population to the risk of NEC. Current management is predominantly supportive, including nil per os (NPO), gastric decompression, broad-spectrum antibiotics, and, in severe cases, urgent surgical resection of the necrotic bowel. The market for therapeutic interventions is constrained by an incomplete understanding of NEC's exact pathogenesis, which is believed to involve a complex interplay of prematurity-related intestinal immaturity, bacterial colonization, and formula feeding. A critical discussion for the group is the substantial long-term morbidity associated with NEC survivors, including short…

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